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C2b is the smallest , enzymatically active, fragment of C3 convertase in this pathway, C4b2b (NB: [[Complement system#Complement protein fragment nomenclature|some sources now refer]] to the larger fragment of C2 as C2b, making the C3 convertase C4b2b, whereas older sources refer to the larger fragment of C2 as C2a, making the C3 convertase C4b2a). The smaller fragment, C2a (or C2b, depending on the source) is released into the fluid phase.<ref name="c2 fragment structure">{{cite journal | vauthors = Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV | title = The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation | journal = Acta Crystallographica D | volume = 65 | issue = Pt 3 | pages = 266–274 | year = 2009 | pmid = 19237749 | pmc = 2651757 | doi = 10.1107/S0907444909000389 }}</ref>
[[File:Protein_C2_PDB_2i6q.png|thumb|'''Complement C2''' is a protein that in humans is encoded by the C2 gene.]]
'''In the Molecular Biology,''' the [https://www.sciencedirect.com/topics/medicine-and-dentistry/complement-component-c2 deficiency of Complement Component 2 i]s a disorder that causes a major effect in the immune system, resulting in a form of immunodeficiency. This effect results in an inability to protect the body against any foreign invader. Complement component 2 deficiency is also connected with an increased risk of developing autoimmune disorders, such as systemic vasculitis. Complement deficiencies is a challenge to understand due to insufficient clinical trails. Using a hemolytic-plaque assay, RNA extraction, and blot analysis, it is fair to note that complement component 2 deficiency is a result of pre-translational regulatory detect in C2 gene expression. This detects a lack of synthesis within the C2 protein. This deficiency can be further understood by incorporating plasma protein deficiencies, especially those in tissue macrophages. It is also important to note that Complement component 2 deficiency can be caused by genetic and environmental factors. In genetic inheritance, Autosomal recessive conditions are inherited with mutations in both copies of the gene where parents of autosomal recessive condition typically do not show symptoms.
== Treatment and Management ==
'''Complement deficiency''' is managed on a case-by-case basis with antibiotics and regular visits with an immunologist. Patients should be aware of symptoms of meningococcal infection and receive routine vaccinations.
== Patient Education ==
Patients and parents should be educated on the symptoms of serious illness and seek care immediately. Vaccination is an important preventive measure for the deficiency of complement component 2. Early diagnosis, antibiotic prophylaxis, and vaccinations can help prevent life-threatening infections in hereditary C2 deficiency.
== Promoting Health Care Outcomes ==
The interprofessional team must be aware of the clinical features of patients with complement deficiency or immunodeficiency, and refer them to allergist/immunologists when necessary.
== References ==
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