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=== Prevention ===
There exist multiple transcription and translation mechanisms to prevent lethality due to deleterious mutations in the coding region. Such measures include [[Proofreading (biology)|proofreading]] by some [[DNA polymerase|DNA Polymerases]] during replication, [[DNA mismatch repair|mismatch repair]] following replication,<ref>DNA proofreading and repair. (n.d.). Retrieved from <nowiki>https://www.khanacademy.org/science/high-school-biology/hs-molecular-genetics/hs-discovery-and-structure-of-dna/a/dna-proofreading-and-repair</nowiki>. {{bare URL inline|date=May 2023}}</ref> and the '[[Wobble hypothesis|Wobble Hypothesis]]' which describes the [[Degeneracy (biology)|degeneracy]] of the third base within an mRNA codon.<ref>Peretó J. (2011) Wobble Hypothesis (Genetics). In: Gargaud M. et al. (eds) Encyclopedia of Astrobiology. Springer, Berlin, Heidelberg</ref>
== Constrained coding regions (CCRs) ==
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