Coding region: Difference between revisions

Revision as of 08:17, 7 May 2023

Revision as of 02:47, 22 May 2023

Line 46:

=== Prevention ===

There exist multiple transcription and translation mechanisms to prevent lethality due to deleterious mutations in the coding region. Such measures include [[Proofreading (biology)|proofreading]] by some [[DNA polymerase|DNA Polymerases]] during replication, [[DNA mismatch repair|mismatch repair]] following replication,<ref>{{Cite web |title=DNA proofreading and repair. (n.d.article). Retrieved from <nowiki>|url=https://www.khanacademy.org/science/high-school-biology/hsdna-molecularas-genetics/hs-discovery-andthe-structure-ofgenetic-material/dna-replication/a/dna-proofreading-and-repair</nowiki>. {{bare URL inline|access-date=May 2023-05-22 |website=Khan Academy |language=en}}</ref> and the '[[Wobble hypothesis|Wobble Hypothesis]]' which describes the [[Degeneracy (biology)|degeneracy]] of the third base within an mRNA codon.<ref>Peretó J. (2011) Wobble Hypothesis (Genetics). In: Gargaud M. et al. (eds) Encyclopedia of Astrobiology. Springer, Berlin, Heidelberg</ref>

== Constrained coding regions (CCRs) ==