When searching "intraperitoneal injections" a majority of the results relate to the use of IP injections in murine or rat models in order to study the effect of some drug or chemical. Intraperitoneal injections are the preferred method of administration in many experimental studies due to the quick onset of effects post injection. This allows researchers to observe the effects of a drug in a shorter period of time, and allows them to study the effects of drugs on multiple organs that are in the peritoneal cavity at once. In order to effectively administer drugs through IP injections, the stomach of the animal is exposed, and the injection is given in the lower abdomen. The most efficient method to inject small animals is a two-person method where one holds the rodent and the other person injects the rodent at about 10 to 20 degrees in mice and 20 to 45 degrees in rats. The holder retains the arms of the animal and tilts the head lower than the abdomen to create optimal space in the peritoneal cavity.<ref name="Laferriere Pang"/>
There has been some debate on whether intraperitoneal injections are the best route of administration for experimental animal studies. It was concluded in a review article that utilizing IP injections to administer drugs to laboratory rodents in experimental studies is acceptable when being applied to proof-of-concept studies.<ref>{{cite journal |last1=Al Shoyaib |first1=A. |last2=Archie |first2=S.R. |last3=Karamyan |first3=V.T. |title=Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies? |journal=Pharm Res |date=2020 |volume=37 |issue=12 |page=12 |doi=10.1007/s11095-019-2745-x|pmid=31873819 |pmc=7412579 }}</ref>
