Reference ranges for blood tests: Difference between revisions

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===Plasma or whole blood===
In this article, all values (except the ones listed below) denote [[blood plasma]] concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside [[red blood cells]] (RBCs) is negligible. The precise factor depends on [[hematocrit]] as well as amount inside RBCs. Exceptions are mainly those values that denote total blood concentration, and in this article they are:<ref name="pmid33274357">{{cite journal| author=Bransky A, Larsson A, Aardal E, Ben-Yosef Y, Christenson RH| title=A Novel Approach to Hematology Testing at the Point of Care. | journal=J Appl Lab Med | year= 2021 | volume= 6 | issue= 2 | pages= 532-542532–542 | pmid=33274357 | doi=10.1093/jalm/jfaa186 | pmc=7798949 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33274357 }} </ref>
* All values in ''Hematology – red blood cells'' (except ''hemoglobin in plasma'')
* All values in ''Hematology – white blood cells''
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===Variability===
{{Further|Reference range}}
References range may vary with age, sex, race, pregnancy,<ref>{{Cite journal | doi = 10.1097/AOG.0b013e3181c2bde8| pmid = 19935037| title = Pregnancy and Laboratory Studies| journal = Obstetrics & Gynecology| volume = 114| issue = 6| pages = 1326–31| year = 2009| last1 = Abbassi-Ghanavati | first1 = M. | last2 = Greer | first2 = L. G. | last3 = Cunningham | first3 = F. G. | s2cid = 24249021}}</ref> diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as [[Accuracy and precision|inaccuracy]], lack of [[standardisation]], lack of [[certified reference materials|certified reference material]] and differing [[epitope|antibody reactivity]].<ref>{{cite journal|last=Armbruster|first=David|author2=Miller |title=The Joint Committee for Traceability in Laboratory Medicine (JCTLM): A Global Approach to Promote the Standardisation of Clinical Laboratory Test Results|journal=The Clinical Biochemist Reviews|date=August 2007|volume=28|issue=3|pages=105–14|pmc=1994110|pmid=17909615}}</ref> Also, reference ranges may be inaccurate when the reference groups used to establish the ranges are small.<ref>{{cite journal|title=Sample Sizes for Prediction Intervals|author=William Q. Meeker & Gerald J. Hahn|doi=10.1080/00224065.1982.11978821|journal=Journal of Quality Technology|volume=14|year=1982|issue=4|pages=201–206 }}</ref>
 
==Sorted by concentration==
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| [[CA-125]] || || 30,<ref name=gp-ca125>[http://www.gpnotebook.co.uk/simplepage.cfm?ID=-100270014 GP Notebook > range (reference, ca-125)] Retrieved on Jan 5, 2009</ref> 35<ref>[http://www.clinlabnavigator.com/Test-Interpretations/ca-125.html ClinLab Navigator > Test Interpretations > CA-125] Retrieved on March 8, 2011</ref> || kU/L or U/mL ||
|-
|rowspan=3| [[Carcinoembryonic antigen]] (CEA) || Non-smokers, 50 years || 3.4,<ref name=uppsala/> 3.6<ref name=bjerner>{{cite journal |vauthors=Bjerner J, Høgetveit A, Wold Akselberg K, etal |s2cid=12545738 |title=Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study |journal=Scandinavian Journal of Clinical and Laboratory Investigation |volume= 68|issue= 8|pages=703–13 |date=June 2008 |pmid=18609108 |doi=10.1080/00365510802126836 |url=https://figshare.com/articles/journal_contribution/Reference_intervals_for_carcinoembryonic_antigen_CEA_CA125_MUC1_Alfa_foeto_protein_AFP_neuron_specific_enolase_NSE_and_CA19_9_from_the_NORIP_study/11808120 }}</ref> ||rowspan=3| μg/L ||
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|| Non-smokers, 70 years || 4.1<ref name=bjerner/> ||