Structural alignment: Difference between revisions

Revision as of 19:49, 11 May 2023

Revision as of 15:54, 24 July 2023

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|pmc=5479680

|doi-access=free

}}</ref><ref name="Malmstrom" /><ref name="robetta" /> These decoys are notorious for getting local fragment motif structure correct, and forming some kernels of correct 3D tertiary structure but getting the full length tertiary structure wrong. In this twilight remote homology regime, Mammoth's e-values for the CASP<ref name="casp11" /> protein structure prediction evaluation have been showshown to be significantly more correlated with human ranking than SSAP or DALI.<ref name=Mammoth /> Mammoths ability to extract the multi-criteria partial overlaps with proteins of known structure and rank these with proper E-values, combined with its speed facilitates scanning vast numbers of decoy models against the PDB data base for identifying the most likely correct decoys based on their remote homology to known proteins.

<ref name="Malmstrom">{{cite journal

|title=Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology