Hippocampal memory encoding and retrieval: Difference between revisions

Revision as of 22:42, 10 February 2023

Revision as of 18:36, 30 July 2023

Line 5:

===HIPER (hippocampal encoding/retrieval) model===

Meta-[[positron emission tomography]] (PET) analysis has lent support toward a division of the hippocampus between caudal and rostral regions.<ref name=b>{{cite journal | last1 = Lepage | first1 = M. | last2 = Habib | first2 = R. | last3 = Tulving | first3 = E. | year = 1998 | title = Lepage, M., Habib, R. & Tulving, E. Hippocampal PET Activations of memory encoding and retrieval: the HIPER model" ''Hippocampus'' 8, 313-322 | journal = Hippocampus | volume = 8 | issue = 4| pages = 313–22 | doi = 10.1002/(SICI)1098-1063(1998)8:4<313::AID-HIPO1>3.0.CO;2-I | pmid = 9744418 | s2cid = 14507536 }}</ref> Scans have demonstrated a uniform variation in blood flow distribution within the hippocampus (and the medial temporal lobe broadly) during the separate processes of episodic encoding and retrieval.<ref name=b /> In the hippocampal encoding/retrieval (HIPER) model, episodic encoding is found to take place within the rostral region of the hippocampus whereas retrieval takes place in the caudal region.<ref name=b /> However, the divide between these regions need not be disjoint, as [[functional magnetic resonance imaging]] (fMRI) data has demonstrated encoding processes occurring within the caudal region.<ref name=b />

HIPER is a model resulting from and therefore a reflection of certain experimental phenomena, but cannot completely explain hippocampal encoding and retrieval on its own.<ref name=b /> Nevertheless, the model suggests a broad division of labor in encoding and retrieval, whether they involve separate regions of the hippocampus or act simultaneously or independently within a single, more inclusive process.