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The first popular computer algebra systems were [[muMATH]], [[Reduce computer algebra system|Reduce]], [[Derive (computer algebra system)|Derive]] (based on muMATH), and [[Macsyma]]; a popular [[copyleft]] version of Macsyma called [[Maxima (software)|Maxima]] is actively being maintained. [[Reduce (computer algebra system)|Reduce]] became free software in 2008.<ref>{{Cite web |title=REDUCE Computer Algebra System at SourceForge |url=http://reduce-algebra.sourceforge.net |access-date=2015-09-28 |website=reduce-algebra.sourceforge.net}}</ref> As of today,{{when|date=October 2016}} the most popular commercial systems are [[Mathematica]]<ref>[http://history.siam.org/oralhistories/gonnet.htm Interview with Gaston Gonnet, co-creator of Maple] {{webarchive|url=https://web.archive.org/web/20071229044836/http://history.siam.org/oralhistories/gonnet.htm|date=2007-12-29}}, SIAM History of Numerical Analysis and Computing, March 16, 2005.</ref> and [[Maple (software)|Maple]], which are commonly used by research mathematicians, scientists, and engineers. Freely available alternatives include [[SageMath]] (which can act as a [[Front and back ends|front-end]] to several other free and nonfree CAS). Other significant significant systems include [[Axiom (computer algebra system)|Axiom]], [[Maxima (software)|Maxima]], [[Magma (computer algebra system)|Magma]], and [[SageMath]].
The movement to web-based applications in the early
More recently, computer algebra systems have been implemented using [[artificial neural networks]], though as of 2020 they are not commercially available<ref>{{Cite web |last=Ornes |first=Stephen |title=Symbolic Mathematics Finally Yields to Neural Networks |url=https://www.quantamagazine.org/symbolic-mathematics-finally-yields-to-neural-networks-20200520/ |access-date=2020-11-04 |website=Quanta Magazine |language=en}}</ref>
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