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Although the species has a reputation for docility, they are very powerful animals – capable of inflicting severe bites and even killing by constriction.<ref>{{Cite news|title=Python Kills Careless Student Zookeeper in Caracas|url=https://www.telegraph.co.uk/news/newstopics/howaboutthat/2622427/Python-kills-careless-student-zookeeper-in-Caracas.html|date=2008-08-26|work=The Telegraph|agency=AP|archive-url=https://ghostarchive.org/archive/20220112/https://www.telegraph.co.uk/news/newstopics/howaboutthat/2622427/Python-kills-careless-student-zookeeper-in-Caracas.html |archive-date=2022-01-12 |url-access=subscription |url-status=live|access-date=2019-02-18|___location=London|issn=0307-1235}}{{cbignore}}</ref><ref>{{Cite journal| vauthors=Chiszar D, Smith HM, Petkus A, Doughery J |date=1993|title=A Fatal Attack on a Teenage Boy by a Captive Burmese Python (''Python molurus bivittatus'') in Colorado|journal=The Bulletin of the Chicago Herpetological Society|publisher=Chicago Herpetological Society|volume=28|issue=#12|page=261 |url=http://www.chicagoherp.org/bulletin/28(12).pdf |archive-url=https://web.archive.org/web/20190218202006/http://chicagoherp.org/bulletin/28(12).pdf |archive-date=2019-02-18|issn=0009-3564}}</ref><ref>{{Cite web |url=http://www.anapsid.org/coloburm.html |title=The Keeping of Large Pythons: Realities and Responsibilities|vauthors=Kaplan M|date=1994 |website=www.anapsid.org|series=Herp Care Collection|access-date=2019-02-18}}</ref><ref>{{Cite news |url=https://www.cbc.ca/news/canada/toronto/python-caused-death-in-ontario-home-in-1992-case-1.1328205 |title=Python Caused Death in Ontario Home in 1992 Case|date=2013-04-13|work=CBC News|access-date=2019-02-17|publisher=Canadian Broadcasting Commission|agency=Canadian Press|department=Toronto News|___location=Toronto|issn=0708-9392}}</ref><ref>{{Cite news|url=https://www.cbc.ca/news/canada/python-linked-deaths-raise-questions-over-exotic-animal-laws-1.1349119|title=Python-linked Deaths Raise Questions over Exotic Animal Laws|vauthors=Davison J|date=2013-08-07|work=CBC News|access-date=2019-02-17 |publisher=Canadian Broadcasting Corporation |department=News|___location=Toronto|issn=0708-9392}}</ref><ref>{{cite web|url=https://assets.documentcloud.org/documents/748680/pages/nevilles-p1-normal.gif |title=Dr. D. H. Evans, Coroner of Ontario, "Inquest into the Death of Mark Nevilles: Verdict of Coroner's Jury" (Brampton, Ontario: June 1992)|website=documentcloud.org|access-date=8 April 2019}}</ref> They also consume large amounts of food, and due to their size, require large, often custom-built, secure enclosures. As a result, some are released into the wild, and become invasive species that devastate the environment. For this reason, some jurisdictions (including Florida, due to the python invasion in the Everglades<ref>{{cite news |vauthors=Burrage G |title=New law makes Burmese python illegal in Florida |url=http://www.abcactionnews.com/dpp/news/state/new-law-makes-burmese-python-illegal-in-florida |date=30 June 2010 |website=Abcactionnews.com |access-date=9 August 2012 |url-status=dead |archive-url=https://web.archive.org/web/20130501023817/http://www.abcactionnews.com/dpp/news/state/new-law-makes-burmese-python-illegal-in-florida |archive-date=2013-05-01}}</ref>) have placed restrictions on the keeping of Burmese pythons as pets. Violators could be imprisoned for more than seven years or fined $500,000 if convicted.
Burmese pythons are opportunistic feeders;<ref>{{Cite journal|vauthors=Orzechowski SC, Romagosa CM, Frederick PC |date=2019-07-01|title=Invasive Burmese pythons (''Python bivittatus'') are novel nest predators in wading bird colonies of the Florida Everglades|journal=Biological Invasions|volume=21|issue=7|pages=2333–2344|doi=10.1007/s10530-019-01979-x|s2cid=102350541|doi-access=free}}</ref> they eat almost any time food is offered, and often act hungry even when they have recently eaten. As a result, they are often overfed, causing [[obesity]]-related problems to be common in captive Burmese pythons.
Like the much smaller [[ball python]], Burmese pythons are known to be easygoing or timid creatures, which means that if cared for properly, they can easily adjust to living near humans.<ref>{{cite web |url=https://www.gbif.org/species/144100053|title=''Python bivittatus'' (Kuhl, 1820)|website=www.gbif.org |access-date=8 April 2019|url-status=dead|archive-date=22 October 2018|archive-url=https://web.archive.org/web/20181022073544/https://www.gbif.org/species/144100053}}</ref>
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