Glycan array: Difference between revisions

Revision as of 14:39, 4 May 2023

Revision as of 22:06, 18 August 2023

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<ref name="Glycan arrays as tools for infectious disease research">{{cite journal|vauthors=Geissner A, Anish C, Seeberger PH|title=Glycan arrays as tools for infectious disease research|journal=Curr Opin Chem Biol|date=Feb 2014|volume=18|pages=38–45|doi=10.1016/j.cbpa.2013.11.013|pmid=24534751}}</ref>

Early on, glycan arrays were proven useful in determining the specificity of the [[Hemagglutinin (influenza)]] of the [[Influenza A virus]] binding to the host and distinguishing across different strains of flu (including avian from mammalian). This was shown with CFG arrays <ref name="Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus">{{cite journal|vauthors=Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA|title=Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus|journal=Science|date=Apr 2006|volume=312|issue=5772|pages=404–410|doi=10.1126/science.1124513|pmid=16543414|bibcode=2006Sci...312..404S|doi-access=free}}</ref> as well as customised arrays.<ref name="Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray">{{cite journal|vauthors=Childs RA, Palma AS, Wharton S, Matrosovich T, Liu Y, Chai W, Campanero-Rhodes MA, Zhang Y, Eickmann M, Kiso M, Hay A, Matrosovich M, Feizi T|title=Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray|journal=Nat Biotechnol|date=Sep 2009 |volume=27|issue=9|pages=797–799|doi=10.1038/nbt0909-797|pmid=19741625|pmc=3771066}}</ref>

Cross-platform benchmarks led to highlight the effect of glycan presentation and spacing on binding.<ref name="Cross-platform comparison of glycan microarray formats">{{cite journal |vauthors=Wang L, Cummings RD, Smith DF, Huflejt M, Campbell CT, Gildersleeve JC, Gerlach JQ, Kilcoyne M, Joshi L, Serna S, Reichardt NC, Parera Pera N, Pieters RJ, Eng W, Mahal LK|title=Cross-platform comparison of glycan microarray formats|journal= Glycobiology |date= Jun 2014|volume=24|issue=6|pages=507–17|doi=10.1093/glycob/cwu019|pmid= 24658466 |pmc=4001710}}</ref>