Glycogen debranching enzyme: Difference between revisions

Revision as of 23:02, 23 July 2022

Revision as of 14:22, 26 August 2023

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{{Infobox_gene}}

{{infobox enzyme

| Name = [[4-alpha-glucanotransferase|4-α-glucanotransferase]]

| image = =

| width =

| caption =

| EC_number = 2.4.1.25

| CAS_number = 9032-09-1

| GO_code = 0004134

| IUBMB_EC_number = 2/4/1/25

| GO_code = 0004134

}}

{{infobox enzyme

| Name = amylo-α-1,6-glucosidase

| EC_number = 3.2.1.33

| CAS_number = 9012-47-9

| GO_code = 0004135

| IUBMB_EC_number = 3/2/1/33

| GO_codeimage = 0004135 =

| imagewidth =

| widthcaption =

| caption =

}}

A '''debranching enzyme''' is a molecule that helps facilitate the [[Glycogenolysis|breakdown]] of [[glycogen]], which serves as a store of glucose in the body, through glucosyltransferase and glucosidase activity. Together with [[phosphorylase]]s, debranching enzymes mobilize [[glucose]] reserves from glycogen deposits in the muscles and liver. This constitutes a major source of energy reserves in most organisms. Glycogen breakdown is highly regulated in the body, especially in the [[liver]], by various hormones including [[insulin]] and [[glucagon]], to maintain a homeostatic balance of blood-glucose levels.<ref name="Hers"/> When glycogen breakdown is compromised by mutations in the glycogen debranching enzyme, metabolic diseases such as [[Glycogen storage disease type III]] can result.<ref name="Song"/><ref name="Bao"/>