Revision as of 04:20, 3 September 2023 edit 50.234.189.42 (talk) Expanded the interpretation and biases section. Removed most of the contrasts with twin studies and intelligence since these are unrelated to GCTA estimates and make this entry not self-contained. Tag: references removed ← Previous edit		Revision as of 04:21, 3 September 2023 edit undo 50.234.189.42 (talk) This section is completely fragmented and provides no additional information specific to GCTA Tag: section blanking Next edit →
Line 115: * LDAK:<ref>Speed et al 2016, [http://biorxiv.org/content/early/2017/01/15/074310 "Re-evaluation of SNP heritability in complex human traits"]</ref> loosens the GCTA assumption that all SNPs, regardless of genotyping quality or frequency, have same averaged expected effect, allowing for potentially finding much more SNP heritability * GREML-IBD:<ref name="Evans2017B">Evans et al 2017, [http://www.biorxiv.org/content/early/2017/07/17/164848 "Narrow-sense heritability estimation of complex traits using identity-by-descent information."]</ref> GCTA for [[identity by descent]], attempting to estimate heritability based on shared genome segments in distant otherwise-unrelated relatives, in order to capture the effect of rarer variants which are not measured by SNP panels or otherwise imputed ~~== Traits ==~~ GCTA estimates frequently find estimates 0.1-0.5, consistent with broadsense heritability estimates (with the exception of personality traits, for which theory & current GWAS results suggest non-additive genetics driven by [[frequency-dependent selection]]<ref name="Verweij2012">[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518920/ "Maintenance of genetic variation in human personality: Testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding"], Verweij et al 2012</ref><ref>[http://www.unm.edu/~gfmiller/newpapers_sept6/penke%202007%20targetarticle.pdf "The Evolutionary Genetics of Personality"], Penke et al 2007; [http://www.larspenke.eu/pdfs/Penke_&_Jokela_in_press_-_Evolutionary_Genetics_of_Personality_Revisited.pdf "The Evolutionary Genetics of Personality Revisited"], Penke & Jokela 2016</ref>). Traits univariate GCTA has been used on (excluding SNP heritability estimates computed using other algorithms such as LD score regression, and bivariate GCTAs which are listed in [[genetic correlation]]) include (point-estimate format: "<math>h^2_{SNP}</math>([[standard error]])"): == See also ==

Genome-wide complex trait analysis: Difference between revisions