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* Evolutionary computing systems such as [[neuroevolution]], [[genetic programming]] and other [[evolutionary algorithm]]s.
* Hiding of code to prevent [[reverse engineering]] (by use of a [[disassembler]] or [[debugger]]) or to evade detection by virus/spyware scanning software and the like.
* Filling 100% of memory (in some architectures) with a rolling pattern of repeating [[opcode]]s, to erase all programs and data, or to [[burn-in]] hardware or perform [[Memory
* [[Executable compression|Compressing]] code to be decompressed and executed at runtime, e.g., when memory or disk space is limited.<ref name="Caldera_1997_DOSSRC"/><ref name="Paul_1997_OD-A3"/>
* Some very limited [[instruction set architecture|instruction sets]] leave no option but to use self-modifying code to perform certain functions. For example, a [[one-instruction set computer]] (OISC) machine that uses only the subtract-and-branch-if-negative "instruction" cannot do an indirect copy (something like the equivalent of "*a = **b" in the [[C (programming language)|C language]]) without using self-modifying code.
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