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'''Evolution in Variable Environment''' ('''EVE''') is a computer program designed to simulate microbial cellular behavior in various environments. The prediction of cellular responses is a rapidly evolving topic in [[systems biology]] and [[computational biology]]. The goal is to predict the behavior a particular organism in response to a set of environmental stimuli ''[[in silico]]''. Such predictions can have a significant impact on preventive medicine, biotechnology, and microbe re-engineering. Computational prediction of behavior has two major components: the integration and simulation of vast biological networks and the creation of external stimuli. Current limitations of the method are: lack of comprehensive experimental data on the various cellular subsystems and inadequate computational algorithms.
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