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Semantic encoding is the processing and encoding of sensory input that has particular meaning or can be applied to a context. Various strategies can be applied such as [[Chunking (psychology)|chunking]] and [[mnemonic]]s to aid in encoding, and in some cases, allow deep processing, and optimizing retrieval.
 
Words studied in semantic or deep encoding conditions are better recalled as compared to both easy and hard groupings of nonsemantic or shallow encoding conditions with response time being the deciding variable.<ref name="Demb">Demb, JB., Desmond, JE., [[John Gabrieli|Gabrieli, JD.]], [[Gary H. Glover|Glover, GH.]], Vaidya, CJ., & Wagner, AD. Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity. The Journal of Neuroscience; 15, 5870-5878.</ref> [[Brodmann area|Brodmann's areas]] 45, 46, and 47 (the left inferior prefrontal cortex or LIPC) showed significantly more activation during semantic encoding conditions compared to nonsemantic encoding conditions regardless of the difficulty of the nonsemantic encoding task presented. The same area showing increased activation during initial semantic encoding will also display decreasing activation with repetitive semantic encoding of the same words. This suggests the decrease in activation with repetition is process specific occurring when words are semantically reprocessed but not when they are nonsemantically reprocessed.<ref name="Demb" /> Lesion and neuroimaging studies suggest that the [[orbitofrontal cortex]] is responsible for initial encoding and that activity in the left lateral prefrontal cortex correlates with the semantic organization of encoded information.<ref name="Frey, Stephen, and Michael Petrides. 2002">Frey, S., & Petrides, M. (2002). Orbitofrontal cortex and memory formation. Neuron, 36(1), 171-176.</ref>
 
===Acoustic encoding===