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→Structure: MW of C1q is 460 kDa. Venkatraman Girija, Umakhanth, et al. "Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation." Proceedings of the National Academy of Sciences 110.34 (2013): 13916-13920. |
Randomguy831 (talk | contribs) m →Function: Found citation for prevalence of SLE among C1q deficient individuals |
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==Function==
[[File:Complement pathway.svg|thumb|270px|left|The classical and alternative complement pathways. C1q is the orange part of the [[C1 complex]] at the top of the image.]]
It is assumed that the globular ends are the sites for multivalent attachment to the complement fixing sites in immune complexed immunoglobulin. Patients with Lupus erythematosus often have deficient expression of C1q. Genetic deficiency of C1q is extremely rare (approximately 75 known cases) although the majority (>90%) of those have [[Systemic lupus erythematosus|SLE]].
C1q associates with C1r and C1s in order to yield the [[C1 complex]] (''C1qr<sup>2</sup>s<sup>2</sup>''), the first component of the serum [[complement system]]. Deficiency of C1q has been associated with [[lupus erythematosus]] and [[glomerulonephritis]].<ref name="entrez ciqa"/>
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