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Randomguy831 (talk | contribs) m →Function: Found citation for prevalence of SLE among C1q deficient individuals |
Randomguy831 (talk | contribs) →Function: IgG types -> IgG Subclasses |
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It is potentially [[Valence (chemistry)|multivalent]] for attachment to the complement fixation sites of [[immunoglobulin]].
The sites are on the CH2 ___domain of [[Immunoglobulin G|IgG]] and, it is thought, on the CH4 ___domain of [[IgM]]. IgG4 cannot bind C1q, but the other three IgG
The appropriate [[peptide sequence]] of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary [[avidity]].
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