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=== Cancer Development ===
Misregulation of PcGs within cellular memory modules often leads to the development of [[Neoplasm|cancerous tumors]]. PcG’s role is to regulate the transcription of developmental genes, which entail processes like [[cell cycle]] progression, [[Cellular differentiation|differentiation]], or [[stem cell]] plasticity. Due to its imperative role in biological processes, mutations among PcGs initiate [[tumorigenesis]]. PcG mutations are more prominent among [[Hormone dependent cancers|hormone-dependent cancers]] where these proteins directly interact with the [[Hormone receptor|hormone receptors]]. It has been discovered that these PcG proteins are able to modulate the tumor microenvironment’s metabolism and immune response, impacting the cancer’s development. PcGs role in tumorigenesis isn’t fully understood although its link to cancer development is widely accepted.<ref>{{Cite journal |last=Parreno |first=Victoria |last2=Martinez |first2=Anne-Marie |last3=Cavalli |first3=Giacomo |date=March 2022 |title=Mechanisms of Polycomb group protein function in cancer |url=https://www.nature.com/articles/s41422-021-00606-6 |journal=Cell Research |language=en |volume=32 |issue=3 |pages=231–253 |doi=10.1038/s41422-021-00606-6 |issn=1748-7838|doi-access=free }}</ref>
== References ==
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