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.<ref name=Cui2003>{{cite journal |vauthors=Cui X, Churchill GA |title=Statistical tests for differential expression in cDNA microarray experiments
|journal= Genome Biology |volume=4 |issue= 4|pages=210
|year=2003 |pmid=12702200 |doi= 10.1186/gb-2003-4-4-210|pmc=154570
|doi-access=free }}</ref> The advantage of using SMCV over p-value (or q-value) is that, if there exist any non-zero true effects for a gene or compound, the estimated SMCV goes to its population value whereas the p-value (or q-value) for testing no mean difference (or zero contrast mean) goes to zero when the sample size increases .<ref name=ZhangSBR2010>{{cite journal |author=Zhang XHD
|title= Strictly standardized mean difference, standardized mean difference and classical t-test for the comparison of two groups
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