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A study from 2017 introduced a new method for identifying the presence of Burmese pythons in southern Florida; this method involves the screening of mosquito blood. Since the introduction of the Burmese python in Florida, mosquito communities use the pythons as hosts even though they are recently introduced.<ref>{{cite journal |vauthors=Reeves LE, Krysko KL, Avery ML, Gillett-Kaufman JL, Kawahara AY, Connelly CR, Kaufman PE |title=Interactions between the invasive Burmese python, ''Python bivittatus'' Kuhl, and the local mosquito community in Florida, USA |journal=PLOS ONE |volume=13 |issue=1 |pages=e0190633 |date=2018-01-17 |pmid=29342169 |pmc=5771569 |doi=10.1371/journal.pone.0190633 |bibcode=2018PLoSO..1390633R |veditors=Paul R |doi-access=free}}</ref>
Invasive Burmese pythons also face certain physiological changes. Unlike their native South Asian counterparts who spend long periods fasting due to seasonal variation in prey availability, pythons in Florida feed year-round due to the constant availability of food. They are also vulnerable to cold stress, with winter freezes resulting in mortality rates of up to 90%. Genomic data suggests natural selection on these populations favors increased thermal tolerance as a result of these high-mortality freezes.<ref>{{cite journal |vauthors=Card DC, Perry BW, Adams RH, Schield DR, Young AS, Andrew AL, Jezkova T, Pasquesi GI, Hales NR, Walsh MR, Rochford MR, Mazzotti FJ, Hart KM, Hunter ME, Castoe TA |display-authors=6 |title=Novel ecological and climatic conditions drive rapid adaptation in invasive Florida Burmese pythons |journal=Molecular Ecology |volume=27 |issue=23 |pages=4744–4757 |date=2018 |pmid=30269397 |doi=10.1111/mec.14885 |doi-access=
They have carried ''Raillietiella orientalis'' (a [[pentastome]] parasitic disease) with them from Southeast Asia. Other reptiles in Florida have become infested, and the parasite appears to have become endemic.<ref name="Waymer-2019" />
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