Human Protein Reference Database: Difference between revisions

Revision as of 23:17, 10 March 2023

Revision as of 00:07, 4 December 2023

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Highlights of HPRD as follows:

* From 10,000 protein–protein interactions (PPIs) annotated for 3,000 proteins in 2003, HPRD has grown to over 36,500 unique PPIs annotated for 25,000 proteins including 6,360 isoforms by the end of 2007.<ref>{{cite journal | author = Mathivanan S. | year = 2006| title = An evaluation of human protein–protein interaction data in the public ___domain | journal = BMC Bioinformatics | volume = 2006 | issue = 7| page = S19 | doi=10.1186/1471-2105-7-s5-s19|display-authors=etal | pmid=17254303 | pmc=1764475| doi-access = free}}</ref>

* More than 50% of molecules annotated in HPRD have at least one PPI and 10% have more than 10 PPIs.

* Experiments for PPIs are broadly grouped into three categories namely in vitro, in vivo and [[yeast two hybrid]] (Y2H). Sixty percent of PPIs annotated in HPRD are supported by a single experiment whereas 26% of them are found to have two of the three experimental methods annotated.

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== Comparison of protein data ==

There are other databases that deal with human proteome (e.g. BioGRID, BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome). Each database has its own style of presenting the data. It is a difficult task for most investigators to compare the voluminous data from these databases in order to conclude strengths and weaknesses of each database. Mathivanan and colleagues <ref name="pmid17254303">{{cite journal|author=Mathivanan S |title=An evaluation of human protein-protein interaction data in the public ___domain |journal=[[BMC Bioinformatics]] |volume=7 Suppl 5 |pages=S19 |year=2006 |pmid=17254303 |pmc=1764475 |doi=10.1186/1471-2105-7-S5-S19 |name-list-style=vanc |author2=Periaswamy B |author3=Gandhi TK |display-authors=3 |last4=Kandasamy |first4=Kumaran |last5=Suresh |first5=Shubha |last6=Mohmood |first6=Riaz |last7=Ramachandra |first7=YL |last8=Pandey |first8=Akhilesh |issue=Suppl 5 |doi-access=free }}</ref> tried to address this issue while analyzing protein data by asking various questions. This analysis will help biologists to choose among these databases based on their needs.

== References ==