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Probio DR10 demonstrated extensive immune-stimulating effects in animal models as well as healthy adult and elderly clinical studies. In a randomised controlled trial (RCT) conducted with children aged 1 to 3 years, it was found that the incidence of high fever and severe acute lower respiratory infections was reduced by 5% and 35% respectively, in children who received the strain along with a prebiotic, in comparison to those who were administered a placebo.<ref name="Sazawal e12164">{{cite journal |last1=Sazawal |first1=Sunil |last2=Dhingra |first2=Usha |last3=Hiremath |first3=Girish |last4=Sarkar |first4=Archana |last5=Dhingra |first5=Pratibha |last6=Dutta |first6=Arup |last7=Verma |first7=Priti |last8=Menon |first8=Venugopal P. |last9=Black |first9=Robert E. |title=Prebiotic and Probiotic Fortified Milk in Prevention of Morbidities among Children: Community-Based, Randomized, Double-Blind, Controlled Trial |journal=PLOS ONE |date=13 August 2010 |volume=5 |issue=8 |pages=e12164 |doi=10.1371/journal.pone.0012164 |doi-access=free |pmc=2921405 |pmid=20730056 |bibcode=2010PLoSO...512164S }}</ref>
A separate RCT also showed that the supplementation of the strain in children aged 2 to 5 years reduced the incidence of diarrhoea and fever by 16.1% and 12.7% respectively during the rainy season.<ref>{{cite journal |last1=Hemalatha |first1=R. |title=A Community-based Randomized Double Blind Controlled Trial of Lactobacillus paracasei and Bifidobacterium lactis on Reducing Risk for Diarrhea and Fever in Preschool Children in an Urban Slum in India |journal=European Journal of Nutrition & Food Safety |date=10 January 2014 |volume=4 |issue=4 |pages=325–341 |doi=10.9734/EJNFS/2014/8280 |doi-access=free }}</ref>
===Modulation of intestinal microbiota===
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