Genetic map function: Difference between revisions

Revision as of 16:56, 30 April 2024

Revision as of 16:57, 30 April 2024

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In [[genetics]], '''mapping functions''' are used to model the relationship between [[Gene mapping|map]] distance (measured in map units or [[Centimorgan|centimorgans]]) between [[Genetic marker|markers]] and [[Genetic recombination|recombination]] frequency between markers. One utility of this is that it allows values to be obtained for genetic distances, which is typically not estimable, from recombination fractions, which typically are.<ref>{{Cite book |last1=Broman |first1=Karl W. |url=https://www.worldcat.org/title/669122118 |title=A guide to QTL mapping with R/qtl |last2=Sen |first2=Saunak |date=2009 |publisher=Springer |isbn=978-0-387-92124-2 |series=Statistics for biology and health |___location=Dordrecht |pages=14 |oclc=669122118}}</ref>

The simplest mapping function is the '''Morgan Mapping Function''', eponymously devised by [[Thomas Hunt Morgan]]. Other well-known mapping functions include the '''Haldane Mapping Function''' introduced by [[J. B. S. Haldane]] in 1919,<ref>{{Cite journal |last=Haldane |first=J.B.S. |date=1919 |title=The combination of linkage values, and the calculation of distances between the loci of linked factors |url=https://www.ias.ac.in/article/fulltext/jgen/008/04/0299-0309 |journal=Journal of Genetics |volume=8 |issue=29 |pages=299–309}}</ref> and the '''Kosambi Mapping Function''' introduced by [[Damodar Dharmananda Kosambi]] in 1944.<ref>{{Cite journal |last=Kosambi |first=D. D. |date=1943 |title=The Estimation of Map Distances from Recombination Values |url=https://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.1943.tb02321.x |journal=Annals of Eugenics |language=en |volume=12 |issue=1 |pages=172–175 |doi=10.1111/j.1469-1809.1943.tb02321.x |issn=2050-1420}}</ref><ref name=":0">{{Cite book |last1=Wu |first1=Rongling |url=https://books.google.com/books?id=-NlGKOEQuEsC&dq=haldane%20mapping%20function&pg=PA65 |title=Statistical genetics of quantitative traits: linkage, maps, and QTL |last2=Ma |first2=Chang-Xing |last3=Casella |first3=George |date=2007 |publisher=Springer |isbn=978-0-387-20334-8 |___location=New York |pages=65 |oclc=141385359}}</ref> OtherFew mapping functions exist but few are used in practice outside thatother ofthan Haldane and Kosambi.<ref name=":1" />

== Morgan Mapping Function ==