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In May 2020, a guidance document was issued by the WHO on criteria for conducting challenge clinical trials and providing clinical care for the participants.<ref name=who-chall/> Following the challenge infection with or without the candidate vaccine, volunteers would be monitored closely in hospitals or clinics managed by physicians treating people with COVID-19 disease and with life-saving resources, if needed.<ref name=eyal/><ref name=callaway/><ref name=who-chall/> Volunteering for a vaccine challenge study during the COVID-19 pandemic is likened to the emergency service of healthcare personnel for COVID-19-infected people, [[firefighter]]s, or [[organ donation|organ donors]].<ref name=eyal/><ref name=callaway/>
In March 2024, funding for a five-year international consortium to develop and run human challenge studies for mucosal (transmission-blocking) Covid vaccines was announced on behalf of the [[European Union]]’s Horizon Europe Programme and the [[Coalition for Epidemic Preparedness Innovations]].<ref name="CEPI March 2024">{{cite web |title=Global consortium plans coordinated human challenge studies in hunt for transmission-blocking coronavirus vaccines {{!}} CEPI |url=https://cepi.net/global-consortium-plans-coordinated-human-challenge-studies-hunt-transmission-blocking-coronavirus |website=cepi.net |access-date=1 May 2024}}</ref> Called Mucosal Immunity in human Coronavirus Challenge (MusiCC) and led by Imperial College London, trials are planned to take place in the UK, Europe, Singapore, and the United States.<ref name="CEPI March 2024" /> Representatives of the consortium and its Scientific Advisory Board met in April 2024 to start the project.<ref name="Imperial News Apr 2024">{{cite web |title=Imperial-led global human challenge consortium kick off ambitious 5-year project {{!}} Imperial News {{!}} Imperial College London |url=https://www.imperial.ac.uk/news/252855/imperial-led-global-human-challenge-consortium-kick/ |website=Imperial News |access-date=1 May 2024 |language=en |date=24 April 2024}}</ref>
==References==
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