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One article reviews the injection of sodium pentobarbital to euthanize rodents intraperitoneally.<ref name="Laferriere Pang"/> Killing the rodent through an intraperitoneal route was originally recommended over other routes such as inhalants because it was thought to be more efficient and ethical. The article overviews whether IP is the best option for euthanization based on evidence associated with welfare implications. It was concluded that there is evidence that IP may not be the best method of euthenasia due to possibilities of missinjection.
Another example of how intraperitoneal injections are used in studies involving rodents is the use of IP for micro-CT contrast enhanced detection of liver tumors.<ref>{{cite journal |last1=Sweeney |first1=N. |last2=Marchant |first2=S. |last3=Martinez |first3=J.D. |title=Intraperitoneal injections as an alternative method for micro-CT contrast enhanced detection of murine liver tumors. |journal=BioTechniques |date=2019 |volume=66 |issue=5 |pages=214–217 |doi=10.2144/btn-2018-0162|pmid=31050302 |s2cid=143433447 |doi-access=free |hdl=10150/634184 |hdl-access=free }}</ref> [[Contrast
An example of how intraperitoneal injections can be optimized is depicted in a study where IP injections are used to deliver anesthesia to mice. This study goes over the dosages, adverse effects, and more of using intraperitoneal injections of anesthesia.<ref>{{cite journal |last1=Arras |first1=M. |last2=Autenried |first2=P. |last3=Rettich |first3=A. |last4=Spaeni |first4=D. |last5=Rulicke |first5=T. |title=Optimization of Intraperitoneal Injection Anesthesia in Mice: Drugs, Dosages, Adverse Effects, and Anesthesia Depth |journal=Comparative Medicine |date=2001 |volume=51 |issue=5 |pages=443–456 |pmid=11924805 |url=https://www.ingentaconnect.com/content/aalas/cm/2001/00000051/00000005/art00008}}</ref>
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