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Building on the previous work of [[John Scott Haldane]]<ref name="haldane" /> (The Haldane model, Royal Navy, 1908) and Robert Workman<ref name="Workman65" /> (M-Values, US-Navy, 1965) and working off funding from [[Shell Oil Company]],<ref name=Pressure94/> Bühlmann designed studies to establish the longest [[Half time (physics)|half-times]] of nitrogen and helium in human tissues.<ref name="AAB1984" /> These studies were confirmed by the ''Capshell'' experiments in the [[Mediterranean Sea]] in 1966.<ref name="Pressure94" /><ref name="pmid6053671" />
===Tissue inert gas exchange===
Inert gas exchange in haldanian models is assumed to be perfusion limited and is governed by the ordinary differential equation
This equation can be solved for constant <math>P_{alv}</math> to give the so-called Haldane equation
<math>P_t(t) = P_{t0} + (P_{t0} - P_{alv}) \cdot e^{-kt}</math>
which is frequently expressed in decompression theory literature as
To calculate the maximum tolerable pressure <math>P_{t.tol}i.g.</math>, the constants <math>a</math> and <math>b</math>, which are derived from the saturation half-time as follows (ZH-L 16 A):▼
<math>
===Alveolar inert gas pressure===
<math>b = 1.005 - \frac{1}{\sqrt[2]{t_{1/2}}}</math>▼
The Bühlmann model uses a simplified version of the respiratory equation to calculate alveolar inert gas pressure
<math>P_{
Where <math>P_{H_{2}0}</math> is the water vapour pressure at 37 degrees centigrade (conventionally defined as 0.0627 bar), <math>P_{CO_{2}}</math> the carbon dioxide pressure (conventionally defined as 0.0534 bar), <math>Q</math> the inspired inert gas fraction, and <math>RQ</math> the respiratory coefficient: the ratio of carbon dioxide production to oxygen consumption. The Buhlmann model sets <math>RQ</math> to 1, simplifying the equation to
<math>P_{alv} = [P_{amb} - P_{H_{2}0}]\cdot Q</math>
===Tissue inert gas limits===
Similarly to Workman, the Bühlmann model specifies an affine relationship between ambient pressure and inert gas saturation limits. However, the Buhlmann model expresses this relationship in terms of absolute pressure
<math>P_{igtol} = a + \frac{P_{amb}}{b}</math>
Where <math>P_{igtol}</math> is the inert gas saturation limit for a given tissue and <math>a</math> and <math>b</math> constants for that tissue.
▲
<math>a = \frac{2\,\text{atm}}{\sqrt[3]{t_{1/2}}}</math>
▲<math>b = 1.005 - \frac{1}{\sqrt[2]{t_{1/2}}}</math>
The <math>b</math> values calculated do not precisely correspond to those used by Bühlmann for tissue compartments 4 (0.7825 instead of 0.7725) and 5 (0.8126 instead of 0.8125).<ref name="Buhlmann-a-b-2002" />
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