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[[File:X-linked dominant.svg|thumb|upright=1.75|X-linked dominant inheritance]]
'''X-linked dominant inheritance''', sometimes referred to as '''X-linked dominance''', is a mode of [[Genetics|genetic]] [[Heredity|inheritance]] by which a [[dominant gene]] is carried on the [[X chromosome]]. As an inheritance pattern, it is less common than the [[X-linked recessive inheritance|X-linked recessive]] type. In medicine, X-linked dominant inheritance indicates that a gene responsible for a [[genetic disorder]] is located on the X chromosome, and only one copy of the [[allele]] is sufficient to cause the disorder when inherited from a parent who has the disorder. In this case, someone who [[Gene expression|expresses]] an X-linked dominant allele will exhibit the disorder and be considered affected.{{cn|date=January 2024}} The pattern of inheritance is sometimes called ''criss-cross inheritance''.<ref>{{Cite book |last=Meneely |first=Philip Mark |url=https://www.worldcat.org/title/951645141 |title=Genetics: genes, genomes, and evolution |last2=Dawes Hoang |first2=Rachel |last3=Okeke |first3=Iruka N. |last4=Heston |first4=Katherine |date=2017 |publisher=Oxford University Press |isbn=978-0-19-879536-0 |___location=Oxford |pages=271 |oclc=951645141}}</ref>
X-linked dominant traits do not necessarily affect males more than females (unlike [[X-linked recessive]] traits). The exact pattern of inheritance varies, depending on whether the father or the mother has the trait of interest. All fathers that are affected by an X-linked dominant disorder will have affected daughters but not affected sons. However, if the mother is also affected then sons will have a chance of being affected, depending on whether a dominant or recessive X chromosome is passed on. When the son is affected, the mother will always be affected. Some X-linked dominant conditions are embryonic lethal in males, making them appear to only occur in females.<ref>{{Cite journal |last=Wettke-Schäfer |first=Roswitha |last2=Kantner |first2=Gisela |date=July 1983 |title=X-linked dominant inherited diseases with lethality in hemizygous males |url=https://doi.org/10.1007/BF00289472 |journal=Human Genetics |language=en |volume=64 |issue=1 |pages=1–23 |doi=10.1007/BF00289472 |issn=1432-1203}}</ref>
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