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{{Redirect|TRPS|the Talyllyn Railway Preservation Society|Talyllyn Railway|Tricho–rhino–phalangeal syndrome|Langer–Giedion syndrome}}
'''Tunable resistive pulse sensing''' ('''TRPS''') is a single-particle technique used to measure the size, concentration and [[zeta potential]] of particles as they pass through a size-tunable [[nanopore]].<ref>{{cite journal | vauthors = Sowerby SJ, Broom MF, Petersen GB | title = Dynamically resizable nanometre-scale apertures for molecular sensing. | journal = Sensors and Actuators B: Chemical. | date = April 2007 | volume = 123 | issue = 1 | pages = 325–330 | doi = 10.1016/j.snb.2006.08.031 | bibcode = 2007SeAcB.123..325S }}</ref><ref name="pmid21434639">{{cite journal | vauthors = Vogel R, Willmott G, Kozak D, Roberts GS, Anderson W, Groenewegen L, Glossop B, Barnett A, Turner A, Trau M | title = Quantitative sizing of nano/microparticles with a tunable elastomeric pore sensor | journal = Analytical Chemistry | volume = 83 | issue = 9 | pages = 3499–506 | date = May 2011 | pmid = 21434639 | doi = 10.1021/ac200195n }}</ref>
The technique adapts the principle of [[resistive pulse sensing]], which monitors current flow through an aperture, combined with the use of tunable nanopore technology, allowing the passage of ionic current and particles to be regulated by adjusting the pore size.<ref name="Roberts_2010">{{cite journal | vauthors = Roberts GS, Kozak D, Anderson W, Broom MF, Vogel R, Trau M | title = Tunable nano/micropores for particle detection and discrimination: scanning ion occlusion spectroscopy | journal = Small | ___location = Weinheim an Der Bergstrasse, Germany | volume = 6 | issue = 23 | pages = 2653–8 | date = December 2010 | pmid = 20979105 | doi = 10.1002/smll.201001129 }}</ref><ref name="Willmott_2010">{{cite journal | vauthors = Willmott GR, Vogel R, Yu SS, Groenewegen LG, Roberts GS, Kozak D, Anderson W, Trau M | title = Use of tunable nanopore blockade rates to investigate colloidal dispersions | journal = Journal of Physics: Condensed Matter| volume = 22 | issue = 45 | pages = 454116 | date = November 2010 | pmid = 21339603 | doi = 10.1088/0953-8984/22/45/454116 | arxiv = 1005.4255 | bibcode = 2010JPCM...22S4116W | s2cid = 11162451 }}</ref> The addition of the tunable nanopore allows for the measurement of a wider range of particle sizes and improves accuracy.<ref name="Roberts_2010" /><ref name="Willmott_2010" />
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