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At a swimming hole the next day, John, his girlfriend Kristin, his best friend Tommy, and Tommy's girlfriend Theresa find Lisa's pet [[Burmese python]], "Lady G". Deputy Greg arrives, mentioning that Lisa is missing, and takes the snake. Lisa's body is found, appearing to have been corroded by acids. Greg suspects John, since he works at a plant that uses acids.
Scientist Anton Rudolph meets with [[NSA]] Special Agent Parker. The cargo is an abnormally large, {{convert|129|ft|m|abbr=on}} [[reticulated python]] genetically engineered in [[Southeast Asia]], blending several species. In the words of Dr. Rudolph, it is, "''a perfect killing machine. A 129-foot all-terrain vehicle, capable of speeds exceeding 50 miles an hour, with skin that can deflect an antitank round, enhanced night vision, and a voracious appetite for human flesh''". The NSA team plans an assault against the Pythonpython.
The Pythonpython kills a real estate agent and the agent's client, leaving behind the client and Roberta's bodies. John arrives as the Pythonpython leaves, furthering suspicion against him. The sheriff shuts down his brother Brian's plant. When the body of the real estate agent is found with the same acid damage, the sheriff orders John arrested.
The NSA team and Anton arrive, telling the sheriff a story about a psychotic rogue operative committing the murders. He does not believe them, but frees John. Kristin, Tommy, Theresa, and he plan to go on a trip the next morning.
The NSA set up base at a water treatment center. They use radar to find where the Pythonpython is likely to be, then have the police set up a perimeter to keep people out of the zone. Believing the Pythonpython to be sleeping, the team wastes most of its ammunition on the Pythonpython's shed skin. Agent Parker realizes the Pythonpython used its skin as a decoy. The Pythonpython kills the team, the sole survivor being Anton who keeps himself standing motionless in front of the creature.
Theresa's morning shower is interrupted by the Pythonpython. ItThough killsshe Tommyescapes, butthe Theresapython escapeseats andTommy. Theresa drives away, withbut the Pythonpython following behindfollows. TheIt followinggets morning,in itfront of her and disables therthe truck. Theresa hides in a crevice.
WJohnWhen Tommy and Theresa do not arrive, John and Kristin findgo looking for them, finding the wrecked truck. Theresa tries warning them as the Pythonpython approaches, but they cannot hear her. John and Kristin escape using Tommy and Theresa's bikes from the truck. They make it to the water treatment center, where Theresa joins them, and find Anton in shock. The group realizes that they must do something about the Pythonpython or it will get to the town. They call Greg on the radio and fill him in on a plan they have devised.
They lure the Pythonpython into the water treatment plant by having it chase John through a shaft, while they set a bomb near the entrance. Kristin drops a line down another shaft for John to escape. They pull John out and the Pythonpython is unable to climb up the shaft. Trapped in the tunnel, the Pythonpython returns to the doorway entrance. The group returns to the entrance to trigger the bomb, but it does not detonate. Anton runs back in to reset it. Anton detonates the charges while confronted by the Pythonpython, sacrificing himself. While the other four are celebrating their success, the Pythonpython emerges unscathed.
The group flees in Greg's police car, planning to penetrate the Pythonpython's hide by luring itthe python into a vat of [[acid]] at John's plating plant. They are able to push the Pythonpython's underbelly into one of the vats, causing the Pythonpython to be killed by the acid.
Six months later, Greg has been accepted into [[FBI Academy|Quantico]] to be an [[FBI]] agent, the plant has been reopened as a bar/bike shop where the death of the Pythonpython is used as a sales tool, and John finds out that Kristin and he are soon to be parents.
==Cast==
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