It is an excellent swimmer, has been reported far out at sea, and has colonized many small islands within its range.
Like all pythons, it is a non-venomous [[Constriction|constrictor]]. In very rare cases, adult humans have been killed, (and in at least eightseven reported cases,[[Man-eating animal|eaten]])swallowed by reticulated pythons.<ref name=wap18>{{cite news |last1=Selk |first1=AviA. |title=A woman went to check her corn — and was swallowed by a python |url=https://www.washingtonpost.com/news/worldviews/wp/2018/06/16/a-woman-went-to-check-her-corn-and-was-swallowed-by-a-python/ |access-date=17 June 2018 |newspaper=The Washington Post}}</ref><ref name=usatoday2017>{{cite news|url=https://www.usatoday.com/story/news/nation-now/2017/03/30/pythons-can-kill-human-minutes-and-swallow-them-hour/99824246/|title= Pythons can kill a human in minutes and swallow them in an hour |author=Sean Rossman|date=2017-03-30|newspaper=[[USA Today]]}}</ref><ref>{{Cite web|url=https://scallywagandvagabond.com/2017/03/akbar-salubiro-indonesian-man-eaten-alive-by-python-found/|title=Photos: Akbar Salubiro Indonesian man eaten alive by python found. |website=Scallywag and Vagabond |last=Koulouris|first=Christopher|access-date=2017-05-28}}</ref><ref>{{Cite web |last=Brown |first=Lee |date=2022-10-25 |title=Missing grandma's body found inside monster python |url=https://nypost.com/2022/10/25/missing-grandmas-body-found-inside-monster-python/ |access-date=2023-04-15 |website=New York Post}}</ref>