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Besides instructions, the ISA defines items in the computer that are available to a program—e.g., [[data type]]s, [[Processor register|registers]], [[addressing mode]]s, and [[Computer memory|memory]]. Instructions locate these available items with register indexes (or names) and memory addressing modes.<ref>{{cite web |title=Organization of Computer Systems: ISA, Machine Language, Number Systems |url=https://www.cise.ufl.edu/~mssz/CompOrg/CDA-lang.html |website=www.cise.ufl.edu |access-date=30 May 2025}}</ref><ref>{{cite web |title=Instruction Set Architecture – Computer Architecture |url=https://www.cs.umd.edu/~meesh/411/CA-online/chapter/instruction-set-architecture/index.html |website=www.cs.umd.edu |access-date=30 May 2025}}</ref>
The ISA of a computer is usually described in a small instruction manual, which describes how the instructions are encoded. Also, it may define short (vaguely) mnemonic names for the instructions. The names can be recognized by a software development tool called an [[assembler (computer programming)|assembler]]. An assembler is a computer program that translates a human-readable form of the ISA into a computer-readable form. [[Disassembler]]s are also widely available, usually in [[debugger]]s and software programs to isolate and correct malfunctions in binary computer programs.<ref>{{cite book |last1=Hennessy |first1=John L. |last2=Patterson |first2=David A. |title=Computer Architecture: A Quantitative Approach |date=23 November 2017 |publisher=[[Morgan Kaufmann Publishers]] |isbn=978-0-12-811906-8 |url=https://google.com/books/edition/Computer_Architecture/cM8mDwAAQBAJ |access-date=30 May 2025 |language=en}}</ref>
ISAs vary in quality and completeness. A good ISA compromises between [[programmer]] convenience (how easy the code is to understand), size of the code (how much code is required to do a specific action), cost of the [[computer]] to interpret the instructions (more complexity means more hardware needed to decode and execute the instructions), and speed of the computer (with more complex decoding hardware comes longer decode time). [[Memory organisation|Memory organization]] defines how instructions interact with the memory, and how memory interacts with itself.
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