Revision as of 01:54, 9 June 2025 edit Citation bot (talk \| contribs) Bots 5,872,501 edits Add: pmc, pmid. \| Use this bot. Report bugs. \| Suggested by Headbomb \| #UCB_toolbar ← Previous edit		Revision as of 04:18, 21 June 2025 edit undo Chris the speller (talk \| contribs) Autopatrolled, Extended confirmed users, Pending changes reviewers 894,449 edits m →BLOSUM: replaced: commonly-used → commonly used Tag: AWB Next edit →
Line 58: It turns out that the BLOSUM62 matrix does an excellent job detecting similarities in distant sequences, and this is the matrix used by default in most recent alignment applications such as [[BLAST (biotechnology)\|BLAST]]. It also turns out the BLOSUM computer code written by Henikoff and Henikoff does not exactly match the description in their paper. Surprisingly, this commonly- used "wrong" version has better search performance.<ref name=article>{{cite journal \|last1=Styczynski \|first1=Mark P \|last2=Jensen \|first2=Kyle L \|last3=Rigoutsos \|first3=Isidore \|last4=Stephanopoulos \|first4=Gregory \|title=BLOSUM62 miscalculations improve search performance \|journal=Nature Biotechnology \|date=March 2008 \|volume=26 \|issue=3 \|pages=274–275 \|doi=10.1038/nbt0308-274 \| pmid=18327232 \|s2cid=205266180 }}</ref> === Differences between PAM and BLOSUM ===

Substitution matrix: Difference between revisions