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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | vauthors = Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Research | volume = 57 | issue = 18 | pages = 4063–9 | date = September 1997 | pmid = 9307294 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/
This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] [[E2F1]]-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = The Journal of Biological Chemistry | volume = 287 | issue = 14 | pages = 10727–37 | date = March 2012 | pmid = 22334682 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | doi-access = free }}</ref>
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