Community Programs for Clinical Research on AIDS: Difference between revisions

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Latest revision as of 16:58, 16 July 2025

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CPCRA was established in 1989<ref>{{cite web |url=https://aspe.hhs.gov/report/inventory-federally-sponsored-hiv-and-hiv-relevant-databases/database-terry-beirn-community-programs-clinical-research-aids-cpcra-observational-data-base-odb |title=An inventory of federally sponsored HIV and HIV-relevant databases. Database:Terry Beirn community programs for clinical research on AIDS (CPCRA) observational database (ODB) |publisher=[[Assistant Secretary for Planning and Evaluation]] (ASPE) |date=7 January 2000 |access-date=21 April 2016 |archive-date=27 April 2016 |archive-url=https://web.archive.org/web/20160427064752/https://aspe.hhs.gov/report/inventory-federally-sponsored-hiv-and-hiv-relevant-databases/database-terry-beirn-community-programs-clinical-research-aids-cpcra-observational-data-base-odb |url-status=dead }}</ref> and included 15 research units. A Statistical Center at the [[University of Minnesota]] was funded from 1990 to 1997.<ref>{{Cite journal|url=https://grantome.com/grant/NIH/N01-AI005073-017|title=Community Programs for Clinical Research on AIDS|first=James|last=Neaton|via=grantome.com}}</ref><ref>{{Cite web | url=http://www.rdatlas.com/portal/portal.cfm?page=grants&applicationid=2296440 | title=RDAtlas | access-date=2016-04-21 | archive-date=2016-05-09 | archive-url=https://web.archive.org/web/20160509120901/http://www.rdatlas.com/portal/portal.cfm?page=grants&applicationid=2296440 | url-status=dead }}</ref>

CPCRA was one of four networks that NIH was using to conduct [[clinical trial]]s that were looking to understand possible therapies for people with HIV infection.<ref>{{cite press release |url=https://aidsinfo.nih.gov/news/123/niaid-research-on-aids |archive-url=https://web.archive.org/web/20130315200305/http://aidsinfo.nih.gov/news/123/niaid-research-on-aids/ |url-status=dead |archive-date=March 15, 2013 |title=NIAID Research on AIDS |publisher=aidsinfo.nih.gov |date= 1 January 1995 |access-date=22 April 2016}}</ref> Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."<ref>{{Cite web |url=http://cpcra.s-3.com/ |title=CPCRA - Community Programs for Clinical Research on AIDS |access-date=2012-08-08 |archive-url=https://archive.today/20130201184215/http://cpcra.s-3.com/ |archive-date=2013-02-01 |url-status=dead }}</ref>

The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and [[unintended consequence]]s of various treatment strategies using available agents to assess long-term [[Immunology|immunologic]], [[virology]] and clinical outcomes. CPCRA trials are designed with nested sub-studies aimed at understanding the [[pathogenesis]] of HIV infection and the public health implications of its treatment.<ref>{{cite web|url=http://www.niaid.nih.gov/DAIDs/pdatguide/cpcra.htm |title=Community Programs for Clinical Research on AIDS (CPCRA) |access-date=April 17, 2007 |url-status=dead |archive-url=https://web.archive.org/web/20070703233645/http://www.niaid.nih.gov/daids/PDATguide/cpcra.htm |archive-date=July 3, 2007 }}</ref>

By 2001, CPCRA had 4,244 people participating in their studies, with trials underway in 17 cities.<ref>{{cite press release |url=https://aidsinfo.nih.gov/news/41/hiv-infection-in-minority-populations |archive-url=https://web.archive.org/web/20130312220450/http://aidsinfo.nih.gov/news/41/hiv-infection-in-minority-populations/ |url-status=dead |archive-date=March 12, 2013 |title=HIV Infections in Minority Populations |publisher=aidsinfo.nih.gov |date =1 June 2002 |access-date=22 April 2016}}</ref>

The [[International Network for Strategic Initiatives in Global HIV Trials]] (INSIGHT) bio-repository system has its roots in the CPCRA.<ref>{{cite journal |pmc=3039520 |title=Designing and managing a flexible and dynamic biorepository system: a 15 year perspective from the CPCRA, ESPRIT, and INSIGHT clinical trial networks |first1=Katherine |last1=Huppler Hullsiek |first2=Michelle |last2=George |first3=Shawn K. |last3=Brown |journal=Curr Opin HIV AIDS |date=November 2010 |volume=5 |issue=6 |pages=538–544 |doi=10.1097/COH.0b013e32833f2058 |pmid=20978398}}</ref>