G-CSF factor stem-loop destabilising element: Difference between revisions

Revision as of 13:49, 16 July 2007

Revision as of 02:28, 16 September 2007

Line 3:

The '''G-CSF factor stem-loop destabilising element (SLDE)''' is an [[cis-regulatory element|RNA element]] secreted by [[fibroblast]]s and endothelial cells in response to the inflammatory mediators [[interleukin-1]] (IL-1) and tumour necrosis factor alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of [[mRNA]] stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail.<ref>{{cite journal | last = Putland | first = RA | coauthors = Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ | year = 2002 | title = RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation | journal = Mol Cell Biol | volume = 22 | pages = 1664&ndash;1673 | id = PMID 11865046}}</ref>

==ReferenceReferences==

{{reflist|1}}

==External linklinks==

* {{Rfam|id=RF00183|name=G-CSF factor stem-loop destabilising element (SLDE)}}

{{molecular-cell-biology-stub}}

[[Category:Cis-regulatory RNA elements]]

{{molecular-cell-biology-stub}}