X-linked dominant inheritance: Difference between revisions

Revision as of 09:21, 13 April 2007

Revision as of 06:33, 1 November 2007

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'''X-linked dominant''' is mode of [[mendelian inheritance|inheritance]] in which a [[gene]] on the [[X chromosome]] is [[dominant]].<ref>[http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/xdomin.html X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital]</ref>. Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women.

This inheritance pattern is less common than [[X-linked recessive]].