[[Image:HPRD.JPG|thumb|right|300 px|The HPRD provides a comprehensive link to any queried protein]]
The '''Human Protein Reference Database''' <ref>Mishra et al. Human protein reference database--2006 update. Nucleic Acids Res. 2006 Jan;34(Database issue):D411-4</ref>,<ref>Peri et al. Development of human [[protein]] reference database as an initial platform for approaching systems biology in humans. Genome Res. 2003 Oct;13:2363-71.</ref> is a protein database accessible through internet. This resource depicts information on human protein functions including [[protein-protein interactions]], [[post-translational modifications]], enzyme-substrate relationships and [[disease]] associations. Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. HPRD [1]also integrates data from [[Human Proteinpedia]], a community portal for integrating human protein data. The data from HPRD can be freely obtained and commercial entities may not use this site without prior licensing authorization. Human Proteinpedia<ref>Mathivanan et al. Human Proteinpedia enables sharing of human protein data. Nat Biotechnology. 2008 Feb;26:164-7</ref> content is freely available for anyone to download and use.
HPRD data is available for download in tab delimited and [[XML]] file formats.
