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==Side Effects and Disadvantages of Phenylbutazone==
Bute, like many NSAIDs, can cause gastrointestinal ulcers and kidney damage if overdosed or used for a prolonged time. Bute may also cause lesions on the horse's mouth and tongue, as well as [[hemorrhage]]s. This is especially true with young, ill, or stressed horses.
Bute may cause severe damage to the lining of the gastrointestinal tract, possibly causing the horse to leak considerable amounts of protein from his blood into his intestine. This may cause edema of the legs and belly. Symptoms of leakage include: decreased appetite, thirst, weight loss, weakness, and if progressed, kidney failure and death.
Do not use Bute in combination with blood thinners or with other NSAIDs (all NSAIDs are additive), or in horses with known kidney or liver problems. When used with other blood thinners (such as Coumadin), such as in horses with laminitis or navicular disease, Phenylbutazone amplifies the anticoagulant effect.
High doses of Phenylbutazone may be considered a violation of rules under some equestrian organizations.▼
Phenylbutazone should be used cautiously in pregnant or nursing mares, as it may be toxic to the embryo and can be transferred via the umbilical cord and by milk.
▲High doses of Phenylbutazone may be considered a violation of rules under some equestrian organizations. Bute may remain in the blood stream 4-5 days after received.
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