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Using high density SNP array to detect LOH allows identification of pattern of allelic imbalance with potential prognostic and diagnostic utilities. This usage of SNP array has a huge potential in cancer diagnostics as LOH is a prominent characteristic of most human cancers. Recent studies based on the SNP array technology have shown that not only solid [[tumor]]s (e.g. [[gastric cancer]], [[Hepatocellular carcinoma|liver cancer]] etc) but also [[leukemia|hematologic malignancies]] ([[Leukemia#Acute Lymphocytic Leukemia (ALL)|ALL]], [[Myelodysplastic syndrome|MDS]], [[Leukemia#Chronic Myelogenous Leukemia (CML)|CML]] etc) have a high rate of LOH due to genomic [[deletion (genetics)|deletions]] or UPD and genomic gains. The results of these studies may help to gain insights into mechanisms of these diseases and to create targeted drugs.
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<references/>
* Affymetrix, 2006. Technology, [online], Address: http://www.affymetrix.com/technology/design/index.affx.
* Barnes, M.R. (2003) Chapter 3: Human Genetic Variation: Databases and Concepts, ''Bioinformatics for geneticists'', edited by Barnes, M.R. and Gray, I.C., John Wiley and Sons, Ltd.
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* Sellick GS, Longman C, Tolmie J, Newbury-Ecob R, Geenhalgh L, Hughes S, Whiteford M, Garrett C, Houlston RS., "Genome-wide linkage searches for Mendelian disease loci can be efficiently conducted using high-density SNP genotyping arrays." ''Nucleic Acids Research''. 32(20):e164. PMID 15561999
* Sheils, O., Finn, S. and O'Leary J. (2003) "Nucleic acid microarray: an overview." ''Current Diagnostic Pathology''. 9:155-158.
* Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 2001;29:308–311. doi: 10.1093/nar/29.1.308.
[[Category:Molecular biology]]
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