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m moved G-CSF factor stem-loop destabilising element (SLDE) to G-CSF factor stem-loop destabilising element over redirect: WP:NC |
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{{Rfam_box|acc=RF00183|description=G-CSF factor stem-loop destabilising element (SLDE)|abbreviation=G-CSF_SLDE|type=Cis-reg;|avg_length=94.2|avg_identity=86|ss=Published; {{PMID|11865046}}|se={{PMID|11865046}}|type=Cis-reg;}}
The '''G-CSF factor stem-loop destabilising element (SLDE)''' is an [[cis-regulatory element|RNA element]] secreted by [[fibroblast]]s and endothelial cells in response to the inflammatory mediators [[interleukin-1]] (IL-1) and tumour necrosis factor alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of [[mRNA]] stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail.<ref>{{cite journal | last = Putland | first = RA | coauthors = Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ | year = 2002 | title = RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation | journal = Mol Cell Biol | volume = 22 | pages = 1664–1673 |
==References==
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