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: The journal titles in the references section are inconsistently formatted. Some have full stops (periods) after the abbreviations while others don't. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 18:19, 2 July 2008 (UTC)
::{{done}} [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Signs and symptoms": "Reynolds' pentad includes the findings of Charcot's triad with the presence of septic shock and mental confusion." What is the frequency of Reynolds' pentad? [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 18:29, 2 July 2008 (UTC)
::{{not done}} None of my reviews give an actual figure. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Diagnosis", "Blood tests": "In the early stages, however, pressure on the liver cells may be the main feature and the tests will resemble those in hepatitis, with elevations in alanine transaminase and aspartate transaminase." Is this really true? I'm reading "Oxford Textbook of Clinical Hepatology" and there's no mention of this. Unfortunately my hospital library doesn't stock "Gastrointestinal clinics of North America". [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 18:25, 2 July 2008 (UTC)
::{{done}} Kinney sources it to PMID 17127193. In my clinical experience this does indeed happen early in the cause of severe cholangitis. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Diagnosis", "Medical imaging": "Compared to ERCP (see below), this modality may show dilation of the bile duct and identifies 38% of bile duct stones; it is relatively poor at identifying stones further down the bile duct." This sentence is rather awkward and should be split.The first part of the sentence: "Compared to ERCP, this modality may show dilation..." doesn't really make sense. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 18:51, 2 July 2008 (UTC)
::{{done}} Unnecessary awkwardness. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Diagnosis", "Medical imaging": "If other causes rather than gallstones are suspected, such as tumors, computed tomography and endoscopic ultrasound...." When I first read this, it seemed that CT and EUS are causes of cholangitis. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 18:58, 2 July 2008 (UTC)
::{{done}} Agree this was convoluted. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: The "Causes" section is inadequate. "Postoperative damage" is mentioned. However there should be more information about iatrogenic causes. As well as biliary surgery, ERCP and PTC themselves can cause cholangitis. There should also be some discussion about the use of prophylactic antibiotics. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 19:08, 2 July 2008 (UTC)
::{{done}} Totally agree that ERCP-associated cholangitis needs discussion. I have sourced this to Williams (recommendation 4.2.11), which states this explicitly. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Pathogenesis": "The duodenum is relatively rich in bacteria also found in the large intestine." It is? The Oxford textbook states "The duodenum and jejunum contain only scant Gram-positive organisms under normal circumstances." Similarly from [http://www.pubmedcentral.nih.gov/pagerender.fcgi?artid=1553007&pageindex=1 Gorbach & Taqabchali]. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 19:34, 2 July 2008 (UTC)
::{{done}} Mea culpa, I misread a line in Kinney. He says that ''in biliary obstruction'', colonic organisms are common in the duodenum. I have simply removed the offending observation. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: <s>In "Pathogenesis", the pressure in the biliary system isn't mentioned. Huang discussed it: "The significance of biliary pressure in cholangitis", pmid: 4888283. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 19:44, 2 July 2008 (UTC)</s>
:: Correction: The importance of the biliary pressure should be emphasized more, perhaps by placing the paragraph higher up. Also, the values of the pressure should be mentioned, as per Huang. [I can do this if necessary.] [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 20:29, 2 July 2008 (UTC)
::{{not done}} Could I leave this to you, Axl? I'm not sure what degree of emphasis you'd like. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
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::{{done}} Kinney seems to be speaking from experience. Any sentence beginning with "it is important" needs revision anyway. I will remove it, because the remainder of the paragraph speaks for itself. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
:In "Pathogenesis": "systemic inflammatory response syndrome (SIRS) comprising fever, rigors, low blood pressure, and increased respiratory rate." SIRS comprises two of four features: fever (or low temperature), tachycardia, tachypnoea and extreme white cell count. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 20:32, 2 July 2008 (UTC)
::{{not done}} The intention was not to reproduce the classical definition of SIRS. Do you think we should follow that definition? [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: The caption for the picture in "Medical imaging" mentions a "nasobiliary drain". I can guess what this means, although I've never heard of it before. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 21:01, 2 July 2008 (UTC)
::Kinney mentions it, and several other sources (e.g. PMID 16374853) attest to its use. Do you think the explanation is adequate? [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Treatment", "Endoscopy": "PTC is not without complications" What complications? [Cholangitis is one.] [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 21:15, 2 July 2008 (UTC)
::{{not done}} Kinney gives an 80% morbidity and 15% mortality, but doesn't give a breakdown of exact complications (such as perforation/biliary peritonitis). I think given that need for PTC is relatively unusual, this should be spun out on the PTC page rather than here. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Treatment", "Endoscopy": "Continual contamination of bile duct by indwelling stents (as may occur in chronic conditions like tumor of the head of pancreas) requires monitoring by repeated radiologic tests and changing of the stents." There should be more information about stents and the need/timing of repeat tests and stent changes. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 21:17, 2 July 2008 (UTC)
::{{not done}} Perhaps that content belongs on the article about stents rather than here. Apart from cholangitis, there are numerous other considerations that are best dealt with in the relevant article IMHO. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: From "Prognosis": "Reported mortality rates for acute cholangitis vary between 2.5% to 65%." That's a massive range. The reference indicates the range 10-30%. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 21:22, 2 July 2008 (UTC)
::{{Done}} Kimura gives that very wide range. However, after 1980 the range 10-30 is given. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
: The reference formatting needs to be standardized: use of ''last'' and ''first'', initials, absence of ''et al'', date format. [[User:Axl|Axl]] ([[User talk:Axl|talk]]) 21:32, 2 July 2008 (UTC)
::{{doing}} Will try to sort this out. [[User:Jfdwolff|JFW]] | [[User_talk:Jfdwolff|<small>T@lk</small>]] 22:26, 2 July 2008 (UTC)
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