Genetic code: Difference between revisions

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The '''genetic code''' is a mapping that [[biological cell]]s use to [[translation (biology)|"translate"]] sequences of three [[nucleotide]] bases (called "triplets" or "[[codon]]s") into [[amino acid]]s. The mapping indicates, for example, that when the sequence "adenine, adenine, adenine" is encountered, the amino acid [[lysine]] should be produced. When the code is followed repeatedly, many amino acids are created, and are strung together to form [[protein]]s.
 
In the process of [[protein biosynthesis]], a sequence of DNA called a [[gene]] is first [[transcription|transcribed]] (copied) into RNA. The RNA is a sequence of repeating units (nucleotide bases). Each position in the RNA may have four possible "values", signified by the four types of bases: adenine, guanine, cytosine and uracil. This sequence of bases encodes a protein. A protein is a sequence of [[amino acid]]s. There are twenty possible amino acids. The RNA is broken up into units of three, called a '''codon'''. Each codon specifies one amino acid. For example, the RNA sequence UUUAAACCC specifies three codons (UUU-, AAA- and CCC), which each specify one amino acid. This RNA sequence, then, encodes a protein sequence three amino acids in length (as we will see, it encodes Phenylalanine-Lysine-Proline). There are sixty-four possible codons.
 
Nearly all living things use the same genetic code. The standard version is given in the following tables, which show what amino acid each of the 4<sup>3</sup> = 64 possible codons specify (Table 1), and what codons specify each of the 20 amino acids involved in translation (Table 2). For instance, GAU codes for the amino acid Asp ([[asparagine]]), and Cys ([[cysteine]]) is coded for by the codons UGU and UGC. These are called forward and reverse codon tables, respectively. The bases in the table below are [[adenine]], [[cytosine]], [[guanine]] and [[uracil]], which are used in the [[mRNA]]; in the [[DNA]], [[thymine]] takes the place of uracil.