Open Notebook Science Challenge: Difference between revisions

Revision as of 06:44, 26 April 2009

Revision as of 06:46, 26 April 2009

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Image:DescriptorChemicalSpace.png|Descriptor Chemical Space for THF: ALOGP vs. MW

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The '''Open Notebook Science Challenge''' is a [[Crowdsourcing]] research project<ref name="ONS Challenge">[http://onschallenge.wikispaces.com/ Open Notebook Science Challenge]</ref> thatwhich allows anyone to contributecollects measurements of the non-aqueous solubility of organic compounds; findings are reported in an [[Open Notebook Science]] manner. Although anyone may contribute, the competition is only open to post-secondary students in the USA and UK.

The challenge in turn forms part of the UsefulChem project, an ongoing, widely[[Open collaborativeNotebook Science]] effort to synthesize and screen potential new anti-malarial drugs<ref name="UsefulChem">[http://usefulchem.wikispaces.com/ UsefulChem]</ref>. Data from the Solubility Challenge will be used to build predictive computational models of solubility for use in optimising syntheses<ref name="predictions">[http://rguha.wordpress.com/2009/01/14/ons-solubility-predictions/ ONS solubility modeling and prediction]</ref>.

The challenge began on September 28, 2008<ref name="began">[http://usefulchem.blogspot.com/2008/09/open-notebook-science-challenge.html The beginning of the Open Notebook Science challenge]</ref> and, as of April 2009, involves researchers and their students from at least 4 different institutions<ref name="experiments">[http://onschallenge.wikispaces.com/list+of+experiments List of experiments]</ref> and has resulted in the acquisition of over 400 solubility measurements<ref name=measurements>[http://oru.edu/cccda/sl/chemspace/cs.php Solubility of Organic Compounds in Organic Solvents]</ref>.