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==Genetic algorithms==
In general, we can not use algebraic methods to optimize the QC procedures. Usage of [[enumerative]] methods would be very tedious, especially with multi-rule procedures, as the number of the points of the parameter space to be searched grows exponentially with the number of the parameters to be optimized. [[Optimization (mathematics)|Optimization]] methods based on the [[genetic algorithms]]<ref>Holland, JH. Adaptation in natural and artificial systems. The University of Michigan Press 1975;pp.1-228.</ref><ref>Goldberg DE. Genetic algorithms in search, optimization and machine learning. Addison-Wesley 1989; pp.1-412.</ref><ref>Mitchell M. An Introduction to
In fact, since 1993, GAs have been used successfully to optimize and to design novel QC procedures<ref> Hatjimihail AT. Genetic algorithms based design and [[optimization]] of statistical quality control procedures. [[Clin Chem]] 1993;39:1972-8. [http://www.clinchem.org/cgi/reprint/39/9/1972]</ref><ref>Hatjimihail AT,Hatjimihail TT. Design of statistical quality control procedures using genetic algorithms. In LJ Eshelman (ed): Proceedings of the Sixth International Conference on Genetic Algorithms. [[San Francisco]]: Morgan Kauffman 1995;551-7.</ref><ref>He D, Grigoryan A. Joint statistical design of double sampling x and s charts. European Journal of Operational Research 2006;168:122-142.</ref>.
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