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The '''chemoreceptor trigger zone''' ('''CTZ''') is an area of the [[medulla oblongata|medulla]] that receives inputs from [[blood]]-borne [[drug]]s or [[hormone]]s, and communicates with the [[vomiting center]], to initiate [[vomiting]]. The CTZ is close to the [[area postrema]] on the floor of the [[fourth ventricle]] and is outside of the [[blood-brain barrier]]. The [[neurotransmitter]]s implicated in the control of [[nausea]] and vomiting include [[acetylcholine]], [[dopamine]], [[histamine]] (H-1 receptor), [[substance P]] (NK-1 receptor), and [[serotonin]] (5-HT3 receptor). There are also [[opioid receptor]]s present, which may be the mechanism by which [[opiate]]s cause nausea and vomiting.
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