Automated Imaging Microscope System: Difference between revisions

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Dear wikipedia colleagues, I would like to update you on a issue that has become disturbing to me. A few days ago Wim Crusio and I had a disagreement over the word "Phenomics" which has been used in many scientific publications and online dictionaries. Wim Crusio has been changing the wiki entry to re-direct it to the word "Phenotype" and I have tried to keep the word as a stand alone term. After his repeated failed attempts to redirect the word to "Phenotype" he has decided to carry out a reprehensible vendetta against myself, my work and my co-researcher who passed away in 2008. As you can see by Wim Crusio's edit history on the following items, he started to delete and alter the following items, on April 29, 2010, which was directly after our disagreement over the word "Phenomics" :

Steven A. Garan

Aging Research Centre

Automated Imaging Microscope System

Paola S. Timiras

I hope the contributors to wikipedia do not encourage this kind of childish behavior. If Wim Crusio has a disagreement regarding an issue with any of my wikipedia colleagues, I would hope to stand by them should a person like Wim Crusio carry out a similar campaign. What I find utterly reprehensible is Wim Crusio's sudden interest in my co-researcher of ten years Paola S. Timiras. She passed away in September of 2008 and starting on April 29, 2010, his actions in altering her page are clearly an act driven not my any scientific motivation, but instead by a malicious desire for revenge.

Steven A. Garan

The '''Automated Imaging Microscope System''' (AIMS) was developed by scientists at the [[University of California, Berkeley]] and the [[Aging Research Centre]] (ARC). [[Steven A. Garan]], was the lead scientists that developed the AIMS system along with Warren Freitag, Jason Neudorf and members of the UC Berkeley lab where AIMS was developed and utilized. Many journals articles have been published about the system and the results that it produced. Since the completion of the first version in 1998, newer versions were developed, with the final version being completed in 2007. Empowering investigators to accurately count specific cell populations is essential to all fields of neurobiology. While computer assisted counting technology has been in use for over a decade, advances in an Automated Imaging Microscope System (AIMS), now insure 97% accuracy when comparing computer counts to human counts for both nuclear and cytoplasmic stained tissue. More importantly, regional analysis can now be customized so that only cell populations within specified anatomic regions will be targeted for counting, thus reducing the background noise of non-immunoreactive cells when characterizing specific cell populations. This application was recently used to successfully map the density and distribution of both nuclear expressed estrogen receptor-alpha and cytoplasmicly expressed IGF-1 receptor in specific hypothalamic nuclei. Furthermore, AIMS can now detect intra-hypothalamic differences in receptor expression and measure phenomenon such as lateralization. By using this technology, the evaluation of tissue-level biology can be used to establish neuroendocrine biomarkers of aging, and analyze the neuroendocrine effects of caloric restriction and gene knockout models that extend the lifespan.