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Versione delle 22:55, 25 dic 2010

Versione delle 23:02, 25 dic 2010

Riga 38:

L'angiotensina III ha il 40% dell'azione vasocostrittoria della II, ma il 100% della sua attività di produzione dell'aldosterone.

===AngiotensinAngiotensina IV===

Arg | '''Val-Tyr-Ile-His-Pro-Phe'''

Riga 60:

L'angiotensina II agisce sulla corteccia del [[surrene]] stimolando il rilascio di [[aldosterone]], un ormone che causa a livello renale ritenzione di sodio ed eliminazione di potassio. Elevati livelli di angiotensina II sono responsabili degli ugualmente elevati livelli di aldosterone presenti durante la fase luteale del [[ciclo mestruale]].

===RenalEffetti effectsrenali===

Riga 67:

Quest'ormone causa inoltre il rilascio locale di [[prostaglandine]], che invece lavorano come antagonisti della vasocostrizione renale: l'effetto netto di questi meccanismi competitivi risulta in un accurato controllo della filtrazione, e possono variare sotto regime farmacologico.

==Voci correlate==

{|class="wikitable"

* [[ACE inibitore]]

|+ Renal effects of Angiotensin II

* [[Aldosterone]]

* [[Sistema renina-angiotensina-aldosterone]]

==Note==

|-

!Target

!Action

!Mechanism<ref name=boron771> Unless else specified in table, then ref is: {{cite book |author=Walter F., PhD. Boron |title=Medical Physiology: A Cellular And Molecular Approaoch |publisher=Elsevier/Saunders |___location= |year= 2005|pages= |isbn=1-4160-2328-3 |oclc= |doi=}} Page 771 </ref>

|-

![[Renal artery]] & <BR> [[afferent arterioles]]

| [[vasoconstriction]] || [[Voltage-dependent calcium channel|VDCC]]s → [[calcium|Ca²⁺]] influx

|-

! [[efferent arteriole]]

| [[vasoconstriction]] || (probably) activate [[Angiotensin receptor#AT1|Angiotensin receptor 1]] → Activation of [[gq alpha subunit|G_q]] → ↑[[phospholipase C|PLC]] activity → ↑[[Inositol triphosphate|IP₃]] and [[diacylglycerol|DAG]] → activation of [[Inositol triphosphate receptor|IP₃ receptor]] in [[sarcoplasmic reticulum|SR]] → ↑intracellular Ca²⁺

|-

![[mesangial cell]]s

| contraction → ↓filtration area ||

* activation of [[gq alpha subunit|G_q]] → ↑[[phospholipase C|PLC]] activity → ↑[[Inositol triphosphate|IP₃]] and [[diacylglycerol|DAG]] → activation of [[Inositol triphosphate receptor|IP₃ receptor]] in [[sarcoplasmic reticulum|SR]] → ↑intracellular Ca²⁺

*[[Voltage-dependent calcium channel|VDCC]]s → [[calcium|Ca²⁺]] influx

|-

! [[Tubuloglomerular feedback]]

| Increased sensitivity || Increase in [[afferent arteriole]] responsiveness to signals from [[macula densa]]

|-

! [[renal medulla|medullary]] blood flow

| Reduction ||

|-

|}

==See also==

* [[ACE inhibitor]]

* [[Angiotensin receptor]]

* [[Angiotensin II receptor antagonist]]

* [[Captopril]]

* [[Peptides]]

==References==

{{reflist}}

==Further readingBiblografia==

*{{En}}{{cite journal | author=de Gasparo M, Catt KJ, Inagami T, "et al." |title=International union of pharmacology. XXIII. The angiotensin II receptors |journal=Parmacol Rev. |volume=52 |pages=415–472 |year=2000 |pmid=10977869 | issue=3}}

{{refbegin | 2}}

*{{En}}''Brenner & Rector's The Kidney'', 7th ed., Saunders, 2004.

*{{cite journal | author=de Gasparo M, Catt KJ, Inagami T, "et al." |title=International union of pharmacology. XXIII. The angiotensin II receptors |journal=Parmacol Rev. |volume=52 |pages=415–472 |year=2000 |pmid=10977869 | issue=3}}

*{{En}}''Brenner & RectorMosby's TheMedical KidneyDictionary'', 7th3rd edEd., SaundersCV Mosby Company, 20041990.

*{{En}}''Mosby'sReview of Medical DictionaryPhysiology'', 3rd20th Ed., CVWilliam MosbyF. Ganong, CompanyMcGraw-Hill, 19902001.

*{{En}}''ReviewClinical Physiology of MedicalAcid-Base Physiologyand Electrolyte Disorders'', 20th5th Eded., WilliamBurton FDavid Rose & Theodore W. Ganong,Post McGraw-Hill, 2001.

==Collegamenti esterni==

*''Clinical Physiology of Acid-Base and Electrolyte Disorders'', 5th ed., Burton David Rose & Theodore W. Post McGraw-Hill, 2001

* http://www.my-personaltrainer.it/fisiologia/renina-angiotensina.html

{{PBB_Further_reading

{{portale|biologia|medicina}}

| citations =

[[Categoria:Ormoni]]

*{{cite journal | author=Lees KR, MacFadyen RJ, Doig JK, Reid JL |title=Role of angiotensin in the extravascular system |journal=Journal of human hypertension |volume=7 Suppl 2 |issue= |pages= S7–12 |year= 1993 |pmid= 8230088 |doi= }}

[[Categoria:Proteine]]

*{{cite journal | author=Weir MR, Dzau VJ |title=The renin-angiotensin-aldosterone system: a specific target for hypertension management |journal=Am. J. Hypertens. |volume=12 |issue= 12 Pt 3 |pages= 205S–213S |year= 2000 |pmid= 10619573 |doi=10.1016/S0895-7061(99)00103-X }}

[[Categoria:Rene]]

[[Categoria:Endocrinologia]]

*{{cite journal | author=Berry C, Touyz R, Dominiczak AF, ''et al.'' |title=Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=281 |issue= 6 |pages= H2337–65 |year= 2002 |pmid= 11709400 |doi= }}

[[Categoria:Fisiologia]]

*{{cite journal | author=Sernia C |title=A critical appraisal of the intrinsic pancreatic angiotensin-generating system |journal=JOP |volume=2 |issue= 1 |pages= 50–5 |year= 2002 |pmid= 11862023 |doi= }}

*{{cite journal | author=Varagic J, Frohlich ED |title=Local cardiac renin-angiotensin system: hypertension and cardiac failure |journal=J. Mol. Cell. Cardiol. |volume=34 |issue= 11 |pages= 1435–42 |year= 2003 |pmid= 12431442 |doi=10.1006/jmcc.2002.2075 }}

*{{cite journal | author=Wolf G |title=Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis |journal=Antioxid. Redox Signal. |volume=7 |issue= 9-10 |pages= 1337–45 |year= 2006 |pmid= 16115039 |doi= 10.1089/ars.2005.7.1337 }}

*{{cite journal | author=Cazaubon S, Deshayes F, Couraud PO, Nahmias C |title=[Endothelin-1, angiotensin II and cancer] |journal=Med Sci (Paris) |volume=22 |issue= 4 |pages= 416–22 |year= 2006 |pmid= 16597412 |doi= }}

*{{cite journal | author=Ariza AC, Bobadilla NA, Halhali A |title=[Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48–56 |year= 2007 |pmid= 17569300 |doi= }}

}}

{{refend}}

...

==External links==

* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.953 I04.953]

* {{MeshName|Angiotensins}}

{{Cardiovascular physiology}}

{{Neuropeptides}}

{{Autacoids}}

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[[id:Angiotensin]]

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