Representational oligonucleotide microarray analysis: Difference between revisions

Revision as of 17:11, 16 February 2006

Revision as of 17:12, 16 February 2006

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In cancer the genome becomes very unstable and has specific regions that are deleted that contain tumor supressor or amplified if they contain oncogenes. These amplifications and deletions have also been observed in the normal human population and are refered to as Copy Number Polymorphisms (CNPs). Jonathan Sebat was one of the first researchers to report in the journal 'Science' in 2003 that these CNPs give rise to human genomic variation and may contribute to our phenotypic differences. Tremendous research efforts are being conducted now to understand the role of CNPs in normal human variation and neurological diseases such as autism. By understanding which regions of the genome have undergone copy number polymorphisms in disease, scientists can ultimately identify genes that are overexpressed or deleted and design drugs to compensate for these genes toand cure diseases.

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