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The '''Automated Imaging Microscope System''' (AIMS) was developed by scientists at the [[University of California, Berkeley]] and the [[Aging Research Centre]] (ARC). [[Steven A Garan]], was the lead scientist that developed the AIMS system along with Warren Freitag, Jason Neudorf and members of the [[Paola S. Timiras]] lab at UC Berkeley, where AIMS was developed and utilized. The development of the system was paid for by the Aging Research Centre and the Center for Research and Education on Aging (CREA) at UC Berkeley. Many journals articles have been published about the system and the results that it produced. Since the completion of the first version in 1998, newer versions were developed, with the final version being completed in 2007. Empowering investigators to accurately count specific cell populations is essential to all fields of neurobiology. While computer assisted counting technology has been in use for over a decade, advances in an Automated Imaging Microscope System (AIMS), now insure 97% accuracy when comparing computer counts to human counts for both nuclear and cytoplasmic stained tissue. More importantly, regional analysis can now be customized so that only cell populations within specified anatomic regions will be targeted for counting, thus reducing the background noise of non-immunoreactive cells when characterizing specific cell populations. This application was recently used to successfully map the density and distribution of both nuclear expressed estrogen receptor-alpha and cytoplasmicly expressed IGF-1 receptor in specific hypothalamic nuclei. Furthermore, AIMS can now detect intra-hypothalamic differences in receptor expression and measure phenomenon such as lateralization. By using this technology, the evaluation of tissue-level biology can be used to establish neuroendocrine biomarkers of aging, and analyze the neuroendocrine effects of caloric restriction and gene knockout models that extend the lifespan.
==Publications==
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== External links ==
* Aging Research Centre: http://www.arclab.org
* Center for Research and Education on Aging (CREA): http://crea.berkeley.edu
* Automated Imaging Microscope System (AIMS) http://www.arclab.org/AIMS/
[[Category:Microscopes]]
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