Nkx2-2as: Difference between revisions

Revision as of 07:41, 26 March 2011

Revision as of 09:06, 26 March 2011

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{{Infobox nonhuman protein

| Name = NK2 transcription factor related, locus 2 (Drosophila), antisense

| image =

| width =

| caption =

| Organism = mouse

| TaxID = 10090

| Symbol = Nkx2-2as

| AltSymbols =

| IUPHAR_id =

| ATC_prefix =

| ATC_suffix =

| ATC_supplemental =

| CAS_number =

| CAS_supplemental =

| DrugBank =

| EntrezGene = 100313531

| PDB =

| RefSeqmRNA = NR_030769

| RefSeqProtein =

| UniProt =

| ECnumber =

| Chromosome = 2

| EntrezChromosome = NC_000068.6

| GenLoc_start = 146987678

| GenLoc_end = 147179556

}}

'''Nkx2-2as''' (Nkx2-2 antisense) is a [[long non-coding RNA]]. It is located in the [[cytoplasm]] of the [[cell]]. Nkx2-2as is involved in [[Neural development]]. Overexpression of Nkx2-2as results in increased levels of expression of the [[homeobox]] gene [[NKX2-2 | Nkx2-2]] and enhances induction of the [[Cellular differentiation | differentiation]] of [[oligodendrocytes]].<ref name="pmid18538132">{{cite journal |author=Tochitani S, Hayashizaki Y |title=Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation |journal=Biochem. Biophys. Res. Commun. |volume=372 |issue=4 |pages=691–6 |year=2008 |month=August |pmid=18538132 |doi=10.1016/j.bbrc.2008.05.127 |url=}}</ref><ref>{{Citation

| title = Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System